Sometimes the head being White can put you off. I've seen quite a few Reds that are full bred and nothing like the standard - just a thought........ Some nice red/whites here http://www.irishredandwhitesetterclub.com/
The Irish Setters I've met have had slightly different shaped faces, , and they've all been totally red. So if I had to guess, I'd say 'no', but that's based simply on the ones I've met.
I wondered that as well. We have more dogs coming over from Ireland these days and some have been working English setters, so why not working Irish red and white as well, especially considering they almost died out but for those left working in Ireland.
I actually thought she looked like a Nova Scotia Duck Toller cross Maybe I'm way off but thats what popped into my head the second I seen the pics.
I've got tollers and have seen several toller crosses, and I don't see any trace of toller there. Looks like spaniel cross to me. Lovely looking dog though.